Argot2: a large scale function prediction tool relying on semantic similarity of weighted Gene Ontology terms.

ABSTRACT:

Background

Predicting protein function has become increasingly demanding in the era of next generation sequencing technology. The task to assign a curator-reviewed function to every single sequence is impracticable. Bioinformatics tools, easy to use and able to provide automatic and reliable annotations at a genomic scale, are necessary and urgent. In this scenario, the Gene Ontology has provided the means to standardize the annotation classification with a structured vocabulary which can be easily exploited by computational methods.

Results

Argot2 is a web-based function prediction tool able to annotate nucleic or protein sequences from small datasets up to entire genomes. It accepts as input a list of sequences in FASTA format, which are processed using BLAST and HMMER sea

SUBMITTER: Falda M 

PROVIDER: S-EPMC3314586 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature