Infection of honey bees with acute bee paralysis virus does not trigger humoral or cellular immune responses.

ABSTRACT: We have studied the responses of honey bees at different life stages (Apis mellifera) to controlled infection with acute bee paralysis virus and have identified the haemolymph of infected larvae and adult worker bees as the compartment where massive propagation of ABPV occurs. Insects respond with a broad spectrum of induced innate immune reactions to bacterial infections, whereas defence mechanisms based on RNA interference play a major role in antiviral immunity. In this study, we have determined that honey bee larvae and adult workers do not produce a humoral immune reaction upon artificial infection with ABPV, in contrast to control individuals challenged with Escherichia coli. ABPV-infected bees produced neither elevated levels of specific antimicrobial peptides (AMPs), such as hymeno

SUBMITTER: Azzami K 

PROVIDER: S-EPMC3314816 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature