Integration of microchip electrophoresis with electrochemical detection using an epoxy-based molding method to embed multiple electrode materials.

ABSTRACT: This paper describes the use of epoxy-encapsulated electrodes to integrate microchip-based electrophoresis with electrochemical detection. Devices with various electrode combinations can easily be developed. This includes a palladium decoupler with a downstream working electrode material of either gold, mercury/gold, platinum, glassy carbon, or a carbon fiber bundle. Additional device components such as the platinum wires for the electrophoresis separation and the counter electrode for detection can also be integrated into the epoxy base. The effect of the decoupler configuration was studied in terms of the separation performance, detector noise, and the ability to analyze samples of a high ionic strength. The ability of both glassy carbon and carbon fiber bundle electrodes to analyze a co

SUBMITTER: Johnson AS 

PROVIDER: S-EPMC3314886 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature