The NF-κB subunit c-Rel stimulates cardiac hypertrophy and fibrosis.

ABSTRACT: Cardiac remodeling and hypertrophy are the pathological consequences of cardiovascular disease and are correlated with its associated mortality. Activity of the transcription factor NF-κB is increased in the diseased heart; however, our present understanding of how the individual subunits contribute to cardiovascular disease is limited. We assign a new role for the c-Rel subunit as a stimulator of cardiac hypertrophy and fibrosis. We discovered that c-Rel-deficient mice have smaller hearts at birth, as well as during adulthood, and are protected from developing cardiac hypertrophy and fibrosis after chronic angiotensin infusion. Results of both gene expression and cross-linked chromatin immunoprecipitation assay analyses identified transcriptional activators of hypertrophy, myocyte enhance

SUBMITTER: Gaspar-Pereira S 

PROVIDER: S-EPMC3314915 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature