Ontology highlight
ABSTRACT:
SUBMITTER: Ashrafian H
PROVIDER: S-EPMC3314920 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Cell metabolism 20120301 3
The citric acid cycle (CAC) metabolite fumarate has been proposed to be cardioprotective; however, its mechanisms of action remain to be determined. To augment cardiac fumarate levels and to assess fumarate's cardioprotective properties, we generated fumarate hydratase (Fh1) cardiac knockout (KO) mice. These fumarate-replete hearts were robustly protected from ischemia-reperfusion injury (I/R). To compensate for the loss of Fh1 activity, KO hearts maintain ATP levels in part by channeling amino ...[more]