Lamellipodia-based migrations of larval epithelial cells are required for normal closure of the adult epidermis of Drosophila.

ABSTRACT: Cell migrations are an important feature of animal development. They are, furthermore, essential to wound healing and tumour progression. Despite recent progress, it is still mysterious how cell migration is spatially and temporally regulated during morphogenesis and how cell migration is coordinated with other cellular behaviours to shape tissues and organs. The formation of the abdominal epithelium of Drosophila during metamorphosis provides an attractive system to study morphogenesis. Here, the diploid adult histoblasts replace the polyploid larval epithelial cells (LECs). Using in vivo 4D microscopy, I show that, besides apical constriction and apoptosis, the LECs undergo extensive coordinated migrations. The migrations follow a transition from a stationary (epithelial) to a migratory

SUBMITTER: Bischoff M 

PROVIDER: S-EPMC3314956 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature