SNCA and MAPT genes: Independent and joint effects in Parkinson disease in the Italian population.

ABSTRACT:

Background

Significant efforts have been focused on investigating the contribution of common variants to Parkinson disease (PD) risk. Several independent GWAS and metanalysis studies have shown a genome-wide significant association of single nucleotide polymorphisms (SNPs) in the α-synuclein (SNCA) and microtubule-associated protein tau (MAPT) regions. Here we investigated the role of SNCA and MAPT as PD susceptibility genes in a large Italian population of 904 patients and 891 controls. An evaluation of gene-gene and gene-environment interactions in association with PD was also attempted.

Methods

The SNCA Rep1 microsatellite was genotyped by a fluorescent PCR assay, whereas the SNPlex genotyping system was used to genotype 12 additional markers across the SNCA gene, and 2 S

SUBMITTER: Trotta L 

PROVIDER: S-EPMC3314966 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature