Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome.

ABSTRACT:

Background

A sexual dimorphism exists in the incidence and prevalence of coronary artery disease--men are more commonly affected than are age-matched women. We explored the role of the Y chromosome in coronary artery disease in the context of this sexual inequity.

Methods

We genotyped 11 markers of the male-specific region of the Y chromosome in 3233 biologically unrelated British men from three cohorts: the British Heart Foundation Family Heart Study (BHF-FHS), West of Scotland Coronary Prevention Study (WOSCOPS), and Cardiogenics Study. On the basis of this information, each Y chromosome was tracked back into one of 13 ancient lineages defined as haplogroups. We then examined associations between common Y chromosome haplogroups and the risk of coronary artery disease in cr

SUBMITTER: Charchar FJ 

PROVIDER: S-EPMC3314981 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature