NADPH oxidase 1-mediated oxidative stress leads to dopamine neuron death in Parkinson's disease.

ABSTRACT:

Aim

Oxidative stress has long been considered as a major contributing factor in the pathogenesis of Parkinson's disease. However, molecular sources for reactive oxygen species in Parkinson's disease have not been clearly elucidated. Herein, we sought to investigate whether a superoxide-producing NADPH oxidases (NOXs) are implicated in oxidative stress-mediated dopaminergic neuronal degeneration.

Results

Expression of various Nox isoforms and cytoplasmic components were investigated in N27, rat dopaminergic cells. While most of Nox isoforms were constitutively expressed, Nox1 expression was significantly increased after treatment with 6-hydroxydopamine. Rac1, a key regulator in the Nox1 system, was also activated. Striatal injection of 6-hydroxydopamine increased Nox1 express

SUBMITTER: Choi DH 

PROVIDER: S-EPMC3315177 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature