MUSI: an integrated system for identifying multiple specificity from very large peptide or nucleic acid data sets.

ABSTRACT: Peptide recognition domains and transcription factors play crucial roles in cellular signaling. They bind linear stretches of amino acids or nucleotides, respectively, with high specificity. Experimental techniques that assess the binding specificity of these domains, such as microarrays or phage display, can retrieve thousands of distinct ligands, providing detailed insight into binding specificity. In particular, the advent of next-generation sequencing has recently increased the throughput of such methods by several orders of magnitude. These advances have helped reveal the presence of distinct binding specificity classes that co-exist within a set of ligands interacting with the same target. Here, we introduce a software system called MUSI that can rapidly analyze very large data sets

SUBMITTER: Kim T 

PROVIDER: S-EPMC3315295 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature