Peripheral immune cell gene expression predicts survival of patients with non-small cell lung cancer.

ABSTRACT: Prediction of cancer recurrence in patients with non-small cell lung cancer (NSCLC) currently relies on the assessment of clinical characteristics including age, tumor stage, and smoking history. A better prediction of early stage cancer patients with poorer survival and late stage patients with better survival is needed to design patient-tailored treatment protocols. We analyzed gene expression in RNA from peripheral blood mononuclear cells (PBMC) of NSCLC patients to identify signatures predictive of overall patient survival. We find that PBMC gene expression patterns from NSCLC patients, like patterns from tumors, have information predictive of patient outcomes. We identify and validate a 26 gene prognostic panel that is independent of clinical stage. Many additional prognostic genes ar

SUBMITTER: Kossenkov AV 

PROVIDER: S-EPMC3315526 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature