Heterogeneity of inflammatory and cytokine networks in chronic plaque psoriasis.

ABSTRACT: The clinical features of psoriasis, characterized by sharply demarcated scaly erythematous plaques, are typically so distinctive that a diagnosis can easily be made on these grounds alone. However, there is great variability in treatment response between individual patients, and this may reflect heterogeneity of inflammatory networks driving the disease. In this study, whole-genome transcriptional profiling was used to characterize inflammatory and cytokine networks in 62 lesional skin samples obtained from patients with stable chronic plaque psoriasis. We were able to stratify lesions according to their inflammatory gene expression signatures, identifying those associated with strong (37% of patients), moderate (39%) and weak inflammatory infiltrates (24%). Additionally, we identified dif

SUBMITTER: Swindell WR 

PROVIDER: S-EPMC3315545 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature