Independent estimation of the frequency of rare CNVs in the UK population confirms their role in schizophrenia.

ABSTRACT:

Background

Several large, rare chromosomal copy number variants (CNVs) have recently been shown to increase risk for schizophrenia and other neuropsychiatric disorders including autism, ADHD, learning difficulties and epilepsy.

Aims

We wanted to examine the frequencies of these schizophrenia-associated variants in a large sample of individuals with non-psychiatric illnesses to better understand the robustness and specificity of the association with schizophrenia.

Methods

We used Affymetrix 500K microarray data from 10,259 individuals from the UK Wellcome Trust Case Control Consortium (WTCCC) who are affected with six non-psychiatric disorders (coronary artery disease, Crohn's disease, hypertension, rheumatoid arthritis, types 1 and 2 diabetes) to establish the frequen

SUBMITTER: Grozeva D 

PROVIDER: S-EPMC3315675 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature