Tumor-derived microvesicles induce proangiogenic phenotype in endothelial cells via endocytosis.

ABSTRACT:

Background

Increasing evidence indicates that tumor endothelial cells (TEC) differ from normal endothelial cells (NEC). Our previous reports also showed that TEC were different from NEC. For example, TEC have chromosomal abnormality and proangiogenic properties such as high motility and proliferative activity. However, the mechanism by which TEC acquire a specific character remains unclear. To investigate this mechanism, we focused on tumor-derived microvesicles (TMV). Recent studies have shown that TMV contain numerous types of bioactive molecules and affect normal stromal cells in the tumor microenvironment. However, most of the functional mechanisms of TMV remain unclear.

Methodology/principal findings

Here we showed that TMV isolated from tumor cells were taken up by NEC

SUBMITTER: Kawamoto T 

PROVIDER: S-EPMC3316594 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature