Association between hepatic steatosis and entecavir treatment failure in Chinese patients with chronic hepatitis B.

ABSTRACT:

Background

The coexistence of HBV infection and nonalcoholic fatty liver disease (NAFLD) becomes characteristic of liver disease in China, with unknown bilateral influence. We aimed to investigate the effect of hepatic steatosis, a common hepatocyte change in NAFLD, on antiviral therapy in patients with chronic hepatitis B (CHB).

Methods and findings

We carried out a prospective nested case control study in CHB patients receiving Entecavir for initial antiviral therapy, by recording demographic, anthropometric and clinical data at baseline, 24(wk), 48(wk) and 96(wk). Univariate analysis and multivariate logistic regression were applied to find out independent factors of hepatic steatosis and Entecavir treatment failure. The rates of HBV-DNA clearance, HBeAg seroconversion an

SUBMITTER: Jin X 

PROVIDER: S-EPMC3316632 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature