The abundance of deleterious polymorphisms in humans.

ABSTRACT: Here I show a gradual decline in the proportion of deleterious nonsynonymous SNPs (nSNPs) from tip to root of the human population tree. This study reveals that up to 48% of nSNPs specific to a single genome are deleterious in nature, which underscores the abundance of deleterious polymorphisms in humans.

SUBMITTER: Subramanian S 

PROVIDER: S-EPMC3316666 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature