Analysis of high accuracy, quantitative proteomics data in the MaxQB database.

ABSTRACT: MS-based proteomics generates rapidly increasing amounts of precise and quantitative information. Analysis of individual proteomic experiments has made great strides, but the crucial ability to compare and store information across different proteome measurements still presents many challenges. For example, it has been difficult to avoid contamination of databases with low quality peptide identifications, to control for the inflation in false positive identifications when combining data sets, and to integrate quantitative data. Although, for example, the contamination with low quality identifications has been addressed by joint analysis of deposited raw data in some public repositories, we reasoned that there should be a role for a database specifically designed for high resolution and quan

SUBMITTER: Schaab C 

PROVIDER: S-EPMC3316731 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature