Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies.

ABSTRACT:

Background

Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling.

Methods

In a collaborative meta-analysis, we studied Asp358Ala (rs2228145) in IL6R in relation to a panel of conventional risk factors and inflammation biomarkers in 125,222 participants. We also compared the frequency of Asp358Ala in 51,441 patients with coronary heart disease and in 136,226 controls. To gain insight into possible mechanisms, we assessed Asp358Ala in relation to localised gene expression and to

SUBMITTER: IL6R Genetics Consortium Emerging Risk Factors Collaboration 

PROVIDER: S-EPMC3316940 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature