LPS counter regulates RNA expression of extracellular proteases and their inhibitors in murine macrophages.

ABSTRACT: Besides their evident importance in host defense, macrophages have been shown to play a detrimental role in different pathological conditions, including chronic inflammation, atherosclerosis, and cancer. Regardless of the exact situation, macrophage activation and migration are intimately connected to extracellular matrix degradation. This process is accomplished by multiple proteolytic enzymes, including serine proteases and members of the matrix metalloproteinase family. In this study, we have utilized qPCR arrays to simultaneously analyze the temporal expression pattern of a range of genes involved in extracellular matrix metabolism in the mouse derived-macrophage cell line RAW 264.7 following stimulation with LPS. Our results revealed that LPS induces the expression of matrix metallopr

SUBMITTER: Hald A 

PROVIDER: S-EPMC3317238 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature