Endophenotypes and serotonergic polymorphisms associated with treatment response in obsessive-compulsive disorder.

ABSTRACT:

Objectives

Approximately 40-60% of obsessive-compulsive disorder patients are nonresponsive to serotonin reuptake inhibitors. Genetic markers associated with treatment response remain largely unknown. We aimed (1) to investigate a possible association of serotonergic polymorphisms in obsessive-compulsive disorder patients and therapeutic response to selective serotonin reuptake inhibitors and (2) to examine the relationship between these polymorphisms and endocrine response to intravenous citalopram challenge in responders and non-responders to serotonin reuptake inhibitors and in healthy volunteers.

Methods

Patients with obsessive-compulsive disorder were classified as either responders or non-responders after long-term treatment with serotonin reuptake inhibitors, and both

SUBMITTER: Corregiari FM 

PROVIDER: S-EPMC3317252 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature