Natural history of age-related retinal lesions that precede AMD in mice fed high or low glycemic index diets.

ABSTRACT:

Purpose

Epidemiologic data indicate that people who consume low glycemic index (GI) diets are at reduced risk for the onset and progression of age-related macular degeneration (AMD). The authors sought corroboration of this observation in an animal model.

Methods

Five- and 16-month-old C57BL/6 mice were fed high or low GI diets until they were 17 and 23.5 months of age, respectively. Retinal lesions were evaluated by transmission electron microscopy, and advanced glycation end products (AGEs) were evaluated by immunohistochemistry.

Results

Retinal lesions including basal laminar deposits, loss of basal infoldings, and vacuoles in the retinal pigment epithelium were more prevalent in the 23.5- than in the 17-month-old mice. Within each age group, consumption of a high

SUBMITTER: Weikel KA 

PROVIDER: S-EPMC3317410 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature