Macular function in macular degenerations: repeatability of microperimetry as a potential outcome measure for ABCA4-associated retinopathy trials.

ABSTRACT:

Purpose

To measure macular visual function in patients with unstable fixation, to define the photoreceptor source of this function, and to estimate its test-retest repeatability as a prerequisite to clinical trials.

Methods

Patients (n = 38) with ABCA4-associated retinal degeneration (RD) or with retinitis pigmentosa (RP) were studied with retina-tracking microperimetry along the foveo-papillary profile between the fovea and the optic nerve head, and point-by-point test-retest repeatability was estimated. A subset with foveal fixation was also studied with dark-adapted projection perimetry using monochromatic blue and red stimuli along the horizontal meridian.

Results

Macular function in ABCA4-RD patients transitioned from lower sensitivity at the parafovea to higher

SUBMITTER: Cideciyan AV 

PROVIDER: S-EPMC3317423 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature