Strain specific transcriptional response in Mycobacterium tuberculosis infected macrophages.

ABSTRACT:

Background

Tuberculosis (TB), a bacterial infection caused by Mycobacterium tuberculosis (Mtb) remains a significant health problem worldwide with a third of the world population infected and nearly nine million new cases claiming 1.1 million deaths every year. The outcome following infection by Mtb is determined by a complex and dynamic host-pathogen interaction in which the phenotype of the pathogen and the immune status of the host play a role. However, the molecular mechanism by which Mtb strains induce different responses during intracellular infection of the host macrophage is not fully understood. To explore the early molecular events triggered upon Mtb infection of macrophages, we studied the transcriptional responses of murine bone marrow-derived macrophages (BMM) to infec

SUBMITTER: Koo MS 

PROVIDER: S-EPMC3317440 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature