Combined pedunculopontine-subthalamic stimulation in Parkinson disease.

ABSTRACT:

Objective

To assess the effect of deep brain stimulation (DBS) in the pedunculopontine nucleus (PPN) and caudal zona incerta (cZi)-both separately and in combination-on motor symptoms and regional cerebral blood flow (rCBF) in patients with Parkinson disease (PD).

Methods

Four patients with bilateral cZi and PPN DBS electrodes were rated with the Unified Parkinson's Disease Rating Scale motor subscale (UPDRS-III) when taking and withdrawn from medication. A block of 16 [(15)O]-H(2)O PET resting measurements of rCBF were performed in 4 different states with patients withdrawn from medication: 1) no stimulation, 2) cZi stimulation alone, 3) PPN stimulation alone, 4) combined PPN/cZi stimulation.

Results

When patients were medicated, combined PPN/cZi stimulation produced

SUBMITTER: Khan S 

PROVIDER: S-EPMC3317530 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature