Circadian gene variants and susceptibility to type 2 diabetes: a pilot study.

ABSTRACT:

Background

Disruption of endogenous circadian rhythms has been shown to increase the risk of developing type 2 diabetes, suggesting that circadian genes might play a role in determining disease susceptibility. We present the results of a pilot study investigating the association between type 2 diabetes and selected single nucleotide polymorphisms (SNPs) in/near nine circadian genes. The variants were chosen based on their previously reported association with prostate cancer, a disease that has been suggested to have a genetic link with type 2 diabetes through a number of shared inherited risk determinants.

Methodology/principal findings

The pilot study was performed using two genetically homogeneous Punjabi cohorts, one resident in the United Kingdom and one indigenous to Pa

SUBMITTER: Kelly MA 

PROVIDER: S-EPMC3317653 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature