Skin regeneration in adult axolotls: a blueprint for scar-free healing in vertebrates.

ABSTRACT: While considerable progress has been made towards understanding the complex processes and pathways that regulate human wound healing, regenerative medicine has been unable to develop therapies that coax the natural wound environment to heal scar-free. The inability to induce perfect skin regeneration stems partly from our limited understanding of how scar-free healing occurs in a natural setting. Here we have investigated the wound repair process in adult axolotls and demonstrate that they are capable of perfectly repairing full thickness excisional wounds made on the flank. In the context of mammalian wound repair, our findings reveal a substantial reduction in hemostasis, reduced neutrophil infiltration and a relatively long delay in production of new extracellular matrix (ECM) during sc

SUBMITTER: Seifert AW 

PROVIDER: S-EPMC3317654 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature