The isolation and characterization of β-glucogallin as a novel aldose reductase inhibitor from Emblica officinalis.

ABSTRACT: Diabetes mellitus is recognized as a leading cause of new cases of blindness. The prevalence of diabetic eye disease is expected to continue to increase worldwide as a result of the dramatic increase in the number of people with diabetes. At present, there is no medical treatment to delay or prevent the onset and progression of cataract or retinopathy, the most common causes of vision loss in diabetics. The plant Emblica officinalis (gooseberry) has been used for thousands of years as a traditional Indian Ayurvedic preparation for the treatment of diabetes in humans. Extracts from this plant have been shown to be efficacious against the progression of cataract in a diabetic rat model. Aldose reductase (ALR2) is implicated in the development of secondary complications of diabetes including

SUBMITTER: Puppala M 

PROVIDER: S-EPMC3317655 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature