Multivariate protein signatures of pre-clinical Alzheimer's disease in the Alzheimer's disease neuroimaging initiative (ADNI) plasma proteome dataset.

ABSTRACT:

Background

Recent Alzheimer's disease (AD) research has focused on finding biomarkers to identify disease at the pre-clinical stage of mild cognitive impairment (MCI), allowing treatment to be initiated before irreversible damage occurs. Many studies have examined brain imaging or cerebrospinal fluid but there is also growing interest in blood biomarkers. The Alzheimer's Disease Neuroimaging Initiative (ADNI) has generated data on 190 plasma analytes in 566 individuals with MCI, AD or normal cognition. We conducted independent analyses of this dataset to identify plasma protein signatures predicting pre-clinical AD.

Methods and findings

We focused on identifying signatures that discriminate cognitively normal controls (n = 54) from individuals with MCI who subsequently progr

SUBMITTER: Johnstone D 

PROVIDER: S-EPMC3317783 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature