Methylation of human papillomavirus type 16 genome and risk of cervical precancer in a Costa Rican population.

ABSTRACT:

Background

Previous studies have suggested an association between human papillomavirus type 16 (HPV16) genome methylation and cervical intraepithelial neoplasia grade 3 (CIN3) (ie, cervical precancer) and cancer, but the results have been inconsistent.

Methods

We designed a case-control study within a large prospective cohort of women who underwent multiple screenings for cervical cancer in Guanacaste, Costa Rica. Diagnostic specimens were collected at the time of CIN3 diagnosis (n = 30 case subjects) and persistent HPV16 infection (persistence; n = 35 case subjects), prediagnostic specimens at the first HPV16-positive screening visit (n = 20 CIN3 case subjects; n = 35 persistence case subjects), and control specimens from women with infection clearance within 2 years (n = 3

SUBMITTER: Mirabello L 

PROVIDER: S-EPMC3317880 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature