Predicting protein flexibility through the prediction of local structures.

ABSTRACT: Protein structures are valuable tools for understanding protein function. However, protein dynamics is also considered a key element in protein function. Therefore, in addition to structural analysis, fully understanding protein function at the molecular level now requires accounting for flexibility. However, experimental techniques that produce both types of information simultaneously are still limited. Prediction approaches are useful alternative tools for obtaining otherwise unavailable data. It has been shown that protein structure can be described by a limited set of recurring local structures. In this context, we previously established a library composed of 120 overlapping long structural prototypes (LSPs) representing fragments of 11 residues in length and covering all known local p

SUBMITTER: Bornot A 

PROVIDER: S-EPMC3317885 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature