Stitching together multiple data dimensions reveals interacting metabolomic and transcriptomic networks that modulate cell regulation.

ABSTRACT: Cells employ multiple levels of regulation, including transcriptional and translational regulation, that drive core biological processes and enable cells to respond to genetic and environmental changes. Small-molecule metabolites are one category of critical cellular intermediates that can influence as well as be a target of cellular regulations. Because metabolites represent the direct output of protein-mediated cellular processes, endogenous metabolite concentrations can closely reflect cellular physiological states, especially when integrated with other molecular-profiling data. Here we develop and apply a network reconstruction approach that simultaneously integrates six different types of data: endogenous metabolite concentration, RNA expression, DNA variation, DNA-protein binding, pr

SUBMITTER: Zhu J 

PROVIDER: S-EPMC3317911 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature