A novel intracellular isoform of matrix metalloproteinase-2 induced by oxidative stress activates innate immunity.

ABSTRACT:

Background

Experimental and clinical evidence has pinpointed a critical role for matrix metalloproteinase-2 (MMP-2) in ischemic ventricular remodeling and systolic heart failure. Prior studies have demonstrated that transgenic expression of the full-length, 68 kDa, secreted form of MMP-2 induces severe systolic failure. These mice also had unexpected and severe mitochondrial structural abnormalities and dysfunction. We hypothesized that an additional intracellular isoform of MMP-2, which affects mitochondrial function is induced under conditions of systolic failure-associated oxidative stress.

Methodology and principal findings

Western blots of cardiac mitochondria from the full length MMP-2 transgenics, ageing mice and a model of accelerated atherogenesis revealed a smaller

SUBMITTER: Lovett DH 

PROVIDER: S-EPMC3317925 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature