Detailed analysis of Japanese population substructure with a focus on the southwest islands of Japan.

ABSTRACT: Uncovering population structure is important for properly conducting association studies and for examining the demographic history of a population. Here, we examined the Japanese population substructure using data from the Japan Multi-Institutional Collaborative Cohort (J-MICC), which covers all but the northern region of Japan. Using 222 autosomal loci from 4502 subjects, we investigated population substructure by estimating F(ST) among populations, testing population differentiation, and performing principal component analysis (PCA) and correspondence analysis (CA). All analyses revealed a low but significant differentiation between the Amami Islanders and the mainland Japanese population. Furthermore, we examined the genetic differentiation between the mainland population, Amami Islande

SUBMITTER: Nishiyama T 

PROVIDER: S-EPMC3318002 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature