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Emergence of OXA-48-type carbapenemase-producing Enterobacteriaceae in German hospitals.

ABSTRACT: Nine carbapenem-resistant Enterobacteriaceae isolates collected from eight patients in five German hospitals were investigated. Six isolates produced the OXA-48 carbapenemase, and three isolates produced OXA-162, which is a point mutant form of OXA-48. Both carbapenemase genes were located on IncL/M-type conjugative plasmids. Insertion sequence IS1999 (truncated or not by IS1R) was located upstream of the bla(OXA-48) and bla(OXA-162) genes in all of the isolates. Pulsed-field gel electrophoresis typing indicated the clonal transmission of an OXA-48-producing Klebsiella pneumoniae strain in two hospitals.

SUBMITTER: Pfeifer Y 

PROVIDER: S-EPMC3318349 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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Emergence of OXA-48-type carbapenemase-producing Enterobacteriaceae in German hospitals.

Pfeifer Yvonne Y   Schlatterer Kathrin K   Engelmann Elisabeth E   Schiller Reinhold A RA   Frangenberg Hans Reiner HR   Stiewe Doris D   Holfelder Martin M   Witte Wolfgang W   Nordmann Patrice P   Poirel Laurent L  

Antimicrobial agents and chemotherapy 20120130 4

Nine carbapenem-resistant Enterobacteriaceae isolates collected from eight patients in five German hospitals were investigated. Six isolates produced the OXA-48 carbapenemase, and three isolates produced OXA-162, which is a point mutant form of OXA-48. Both carbapenemase genes were located on IncL/M-type conjugative plasmids. Insertion sequence IS1999 (truncated or not by IS1R) was located upstream of the bla(OXA-48) and bla(OXA-162) genes in all of the isolates. Pulsed-field gel electrophoresis  ...[more]

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