Novel variants of AbaR resistance islands with a common backbone in Acinetobacter baumannii isolates of European clone II.

ABSTRACT: In this study, the genetic organization of three novel genomic antibiotic resistance islands (AbaRs) in Acinetobacter baumannii isolates belonging to group of European clone II (EC II) comM integrated sequences of 18-, 21-, and 23-kb resistance islands were determined. These resistance islands carry the backbone of AbaR-type transposon structures, which are composed of the transposition module coding for potential transposition proteins and other genes coding for the intact universal stress protein (uspA), sulfate permease (sul), and proteins of unknown function. The antibiotic resistance genes strA, strB, tetB, and tetR and insertion sequence CR2 element were found to be inserted into the AbaR transposons. GenBank homology searches indicated that they are closely related to the AbaR seque

SUBMITTER: Seputiene V 

PROVIDER: S-EPMC3318354 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature