Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort.

ABSTRACT:

Background

Exercise tolerance in COPD is only moderately well predicted by airflow obstruction assessed by FEV(1). We determined whether other phenotypic characteristics, including CT scan measures, are independent predictors of 6-min walk distance (6MWD) in the COPDGene cohort.

Methods

COPDGene recruits non-Hispanic Caucasian and African American current and ex-smokers. Phenotyping measures include postbronchodilator FEV(1) % predicted and inspiratory and expiratory CT lung scans. We defined % emphysema as the percentage of lung voxels < -950 Hounsfield units on the inspiratory scan and % gas trapping as the percentage of lung voxels < -856 Hounsfield units on the expiratory scan.

Results

Data of the first 2,500 participants of the COPDGene cohort were analyzed. Part

SUBMITTER: Rambod M 

PROVIDER: S-EPMC3318949 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature