Relation of vascular growth factors with CT-derived measures of body fat distribution: the Framingham Heart Study.

ABSTRACT:

Background

Visceral adiposity is associated with metabolic risk. Given that angiogenesis is a key feature of adipogenesis, variation in the association of levels of circulating vascular growth factors (and their soluble receptors) with distinct body fat compartments may explain differences in the systemic pathogenicity of regional fat depots.

Methods and results

Four body fat compartments [visceral adipose tissue (VAT), sc adipose tissue (SAT), thoracic periaortic fat, and pericardial fat] derived from computed tomography were related to serum concentrations of vascular endothelial growth factor (VEGF), the soluble VEGF receptor (fms-like tyrosine kinase-1), hepatocyte growth factor (HGF), and angiopoietin-2 and its soluble receptor (soluble tyrosine kinase with immunoglobul

SUBMITTER: Kaess BM 

PROVIDER: S-EPMC3319207 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature