Cannabinoids and metabolites in expectorated oral fluid following controlled smoked cannabis.

ABSTRACT:

Background

∆(9)-Tetrahydrocannabinol (THC) in oral fluid (OF) implies cannabis intake, but eliminating passive exposure and improving interpretation of test results requires additional research.

Methods

Ten adult cannabis users smoked ad libitum one 6.8% THC cigarette. Expectorated OF was collected for up to 22 h, and analyzed within 24h of collection. THC, 11-nor-9-carboxy-THC (THCCOOH), cannabidiol, and cannabinol were quantified by 2-dimensional-GCMS.

Results

Eighty specimens were analyzed; 6 could not be collected due to dry mouth. THC was quantifiable in 95.2%, cannabidiol in 69.3%, cannabinol in 62.3%, and THCCOOH in 94.7% of specimens. Highest THC, cannabidiol, and cannabinol concentrations were 22370, 1000, and 1964 μg/l, respectively, 0.25 h after the start o

SUBMITTER: Milman G 

PROVIDER: S-EPMC3319321 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature