Replication of neuroblastoma SNP association at the BARD1 locus in African-Americans.

ABSTRACT:

Background

Neuroblastoma is an often fatal pediatric cancer more frequent in European-American than African-American children. African-American children, however, are at higher risk for the more severe form of neuroblastoma and have worse overall survival than European-American children. Genome-wide association studies (GWAS) have identified several single-nucleotide polymorphisms (SNP) associated to neuroblastoma in children of European descent. Knowledge of their association to neuroblastoma in African-American children is still lacking.

Methods

We genotyped and imputed SNPs located in three gene regions reported to be associated to neuroblastoma in children of European descent, and tested them for association in 390 African-American patients with neuroblastoma compared wi

SUBMITTER: Latorre V 

PROVIDER: S-EPMC3319325 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature