Dense genotyping of candidate gene loci identifies variants associated with high-density lipoprotein cholesterol.

ABSTRACT:

Background

Plasma levels of high-density lipoprotein cholesterol (HDL-C) are known to be heritable, but only a fraction of the heritability is explained. We used a high-density genotyping array containing single-nucleotide polymorphisms (SNPs) from HDL-C candidate genes selected on known biology of HDL-C metabolism, mouse genetic studies, and human genetic association studies. SNP selection was based on tagging SNPs and included low-frequency nonsynonymous SNPs.

Methods and results

Association analysis in a cohort containing extremes of HDL-C (case-control, n=1733) provided a discovery phase, with replication in 3 additional populations for a total meta-analysis in 7857 individuals. We replicated the majority of loci identified through genome-wide association studies and pre

SUBMITTER: Edmondson AC 

PROVIDER: S-EPMC3319351 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature