Catechol-O-methyltransferase genotype predicts pain severity in hospitalized burn patients.

ABSTRACT: Increasing evidence suggests that stress system activation after burn injury may contribute to burn-related pain. If this is the case, then genetic variations influencing the function of important stress system components, such as the enzyme catechol-O-methyltransferase (COMT), may predict pain severity after thermal burn injury. The authors evaluated the association between COMT genotype and pain intensity in 57 individuals hospitalized after thermal burn injury. Consenting participants at four burn centers were genotyped and completed daily 0 to 10 numeric rating scale pain assessments on 2 consecutive days including evaluation of waking, least, and worst pain. The association between COMT genotype and individual pain outcomes was calculated using a linear mixed model adjusting for socio

SUBMITTER: Orrey DC 

PROVIDER: S-EPMC3319634 | biostudies-literature | 2012 Jul-Aug

REPOSITORIES: biostudies-literature