Palladium-catalyzed N-arylation of 2-aminothiazoles.

ABSTRACT: A method for the Pd-catalyzed coupling of 2-aminothiazole derivatives with aryl bromides and triflates is described. Significantly, for this class of nucleophiles, the coupling exhibits a broad substrate scope and proceeds with a reasonable catalyst loading. Furthermore, an interesting effect of acetic acid as an additive is uncovered that facilitates catalyst activation.

SUBMITTER: McGowan MA 

PROVIDER: S-EPMC3319723 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature