MiR-155 is a liposarcoma oncogene that targets casein kinase-1α and enhances β-catenin signaling.

ABSTRACT: Liposarcoma can be an aggressive, debilitating, and fatal malignancy. In this study, we identifed miRNAs associated with the differentiation status of liposarcoma to gain insight into the basis for its progression. miRNA expression profiles determined in human tumors and normal fat specimens identified a dedifferentiated tumor expression signature consisting of 35 miRNAs. Deregulated miRNA expression was confirmed in a second independent sample cohort. The miR-155 was the most overexpressed miRNA and functional investigations assigned an important role in the growth of dedifferentiated liposarcoma cell lines. Transient or stable knockdown of miR-155 retarded tumor cell growth, decreased colony formation, and induced G(1)-S cell-cycle arrest in vitro and blocked tumor growth in murine xenog

SUBMITTER: Zhang P 

PROVIDER: S-EPMC3319789 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature