The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

ABSTRACT: The systematic translation of cancer genomic data into knowledge of tumour biology and therapeutic possibilities remains challenging. Such efforts should be greatly aided by robust preclinical model systems that reflect the genomic diversity of human cancers and for which detailed genetic and pharmacological annotation is available. Here we describe the Cancer Cell Line Encyclopedia (CCLE): a compilation of gene expression, chromosomal copy number and massively parallel sequencing data from 947 human cancer cell lines. When coupled with pharmacological profiles for 24 anticancer drugs across 479 of the cell lines, this collection allowed identification of genetic, lineage, and gene-expression-based predictors of drug sensitivity. In addition to known predictors, we found that plasma cell l

SUBMITTER: Barretina J 

PROVIDER: S-EPMC3320027 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature