Differentiation of schizophrenia patients from healthy subjects by mismatch negativity and neuropsychological tests.

ABSTRACT:

Background

Schizophrenia is a heterogeneous disorder with diverse presentations. The current and the proposed DSM-V diagnostic system remains phenomenologically based, despite the fact that several neurobiological and neuropsychological markers have been identified. A multivariate approach has better diagnostic utility than a single marker method. In this study, the mismatch negativity (MMN) deficit of schizophrenia was first replicated in a Han Chinese population, and then the MMN was combined with several neuropsychological measurements to differentiate schizophrenia patients from healthy subjects.

Methodology/principal findings

120 schizophrenia patients and 76 healthy controls were recruited. Each subject received examinations for duration MMN, Continuous Performance Tes

SUBMITTER: Lin YT 

PROVIDER: S-EPMC3320618 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature