MRI hippocampal and entorhinal cortex mapping in predicting conversion to Alzheimer's disease.

ABSTRACT:

Objective

Using MRI surface morphometry mapping, to evaluate local deformations of the hippocampus, parahippocampal gyrus, and entorhinal cortex in predicting conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD).

Methods

Baseline brain MRI with surface morphological analysis was performed in 130 outpatients with MCI, broadly defined, and 61 healthy controls followed for an average of 4 years in a single site study.

Results

Patients with MCI differed from controls in several regions of the hippocampus and entorhinal cortex, and to a lesser extent in the parahippocampal gyrus. In the MCI sample, Cox regression models were conducted for time to conversion comparing converters to AD (n=31) and non-converters (n=99), controlling for age, sex and educ

SUBMITTER: Devanand DP 

PROVIDER: S-EPMC3320768 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature