Genomic characterisation of the Jk(a-b-) phenotype in Thai blood donors.

ABSTRACT:

Background

The Kidd (JK) blood group antigens are encoded by the JK gene. The rare Jk(a-b-) phenotype can be caused by homozygosity for a silent JK allele. Currently, JK(null) alleles have been identified among different populations; however, information on its presence among Thais is not available.

Materials and methods

Screening for the Jk(a-b-) phenotype by the urea lysis test was performed in 25,340 blood samples from Thai blood donors. The Jk(a-b-) phenotypes were confirmed by an indirect antiglobulin test (IAT). Additionally, polymerase chain reaction amplification and sequence analysis of the JK gene were performed using previously described methods.

Results

Five samples were confirmed as having a Jk(a-b-) phenotype by a urea lysis test and IAT; four of these s

SUBMITTER: Sriwanitchrak P 

PROVIDER: S-EPMC3320777 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature