Interaction of HIV-1 reverse transcriptase ribonuclease H with an acylhydrazone inhibitor.

ABSTRACT: HIV-1 reverse transcriptase is a bifunctional enzyme, having both DNA polymerase (RNA- and DNA-dependent) and ribonuclease H activities. HIV-1 reverse transcriptase has been an exceptionally important target for antiretroviral therapeutic development, and nearly half of the current clinically used antiretrovirals target reverse transcriptase DNA polymerase. However, no inhibitors of reverse transcriptase ribonuclease H are on the market or in preclinical development. Several drug-like small molecule inhibitors of reverse transcriptase ribonuclease H have been described, but little structural information is available about the interactions between reverse transcriptase ribonuclease H and inhibitors that exhibit antiviral activity. In this report, we describe NMR studies of the interaction o

SUBMITTER: Gong Q 

PROVIDER: S-EPMC3320797 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature