Context-specific protein network miner--an online system for exploring context-specific protein interaction networks from the literature.

ABSTRACT:

Background

Protein interaction networks (PINs) specific within a particular context contain crucial information regarding many cellular biological processes. For example, PINs may include information on the type and directionality of interaction (e.g. phosphorylation), location of interaction (i.e. tissues, cells), and related diseases. Currently, very few tools are capable of deriving context-specific PINs for conducting exploratory analysis.

Results

We developed a literature-based online system, Context-specific Protein Network Miner (CPNM), which derives context-specific PINs in real-time from the PubMed database based on a set of user-input keywords and enhanced PubMed query system. CPNM reports enriched information on protein interactions (with type and directionality),

SUBMITTER: Chowdhary R 

PROVIDER: S-EPMC3321019 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature