Striatal hypertrophy and its cognitive effects in new-onset benign epilepsy with centrotemporal spikes.

ABSTRACT:

Purpose

Benign epilepsy with centrotemporal spikes (BECTS), the most common childhood epilepsy syndrome, is a neurodevelopmental disorder with a genetic influence. Despite its signature electroencephalographic pattern and distinct focal motor seizure semiology, little is known about the underlying brain anatomic alteration and the corresponding cognitive consequences. Given the motor manifestations of seizures in BECTS, we hypothesize that anatomic networks in BECTS involve a distributed corticostriatal circuit.

Methods

We investigated volumetric differences and shape deformities of caudate, putamen, pallidum, and thalamus in a group of children with new- and recent-onset BECTS (N =  3) compared to healthy controls (N = 54). We correlated specific subcortical volumes in BECT

SUBMITTER: Lin JJ 

PROVIDER: S-EPMC3321058 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature